🔬 Evidence-Based
Not Trends.
The Data.
Every ingredient is backed by peer-reviewed clinical research. Below you'll find the studies we reference — with direct links to PubMed.
14
Studies Referenced
1970s
Research Dating Back To
100%
Peer-Reviewed Sources
PubMed
All Studies Verifiable
2009
Phytotherapy Research
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment
Double-blind, parallel-group, placebo-controlled trial. 50–80 year old subjects with cognitive concerns showed significantly higher cognitive function scores after 16 weeks of Lion's Mane supplementation. Scores declined after stopping supplementation.
2013
Int. Journal of Medicinal Mushrooms
Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells
Identified hericenones and erinacines as the key bioactive compounds that cross the blood-brain barrier and stimulate NGF synthesis. Provides the mechanistic basis for Lion's Mane cognitive effects.
2010
Journal of Medicinal Food
Mood and well-being changes after 4-week Hericium erinaceus supplementation
Randomized controlled trial in 30 women. Researchers observed differences in mood and well-being scores in the Lion's Mane group versus placebo after 4 weeks. The proposed mechanism involves NGF-related signaling pathways.
2015
PLOS ONE
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
Demonstrated that Reishi polysaccharides significantly modulate the gut microbiome, reduce metabolic endotoxemia, and decrease fat tissue inflammation. Beta-glucans shown to be prebiotic, supporting beneficial gut bacteria.
View on PubMed ↗
Chang et al., 2015 · PMID: 26512010
2012
Evidence-Based Complementary Medicine
Sedative-Hypnotic Activity of Alcohol Extract of Ganoderma lucidum
Reishi extract demonstrated significant sedative and sleep-promoting effects. Ganoderic acids were found to modulate GABA receptors and reduce time to sleep onset, supporting traditional use for sleep quality improvement.
View on PubMed ↗
Cui et al., 2012 · PMID: 22203880
2016
Journal of Dietary Supplements
Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation
Randomized, double-blind, placebo-controlled crossover trial. Participants who supplemented with Cordyceps for 3 weeks showed significant improvements in VO₂ max, time to exhaustion, and anaerobic threshold versus placebo — without stimulant side effects.
2008
Metabolism
Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus
Randomized, double-blind, placebo-controlled pilot trial. Researchers observed support for fasting glucose, triglyceride, and LDL cholesterol markers versus placebo over 3 months in adults with metabolic concerns. Results may not apply to healthy individuals with markers in the normal range.
2012
Indian Journal of Psychological Medicine
A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults
64 subjects under chronic stress received 300mg KSM-66 twice daily for 60 days. Researchers observed meaningful reductions in serum cortisol versus placebo, along with improvements across stress-assessment scales including perceived stress and overall well-being.
2019
Medicine (Baltimore)
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract
Randomized, double-blind, placebo-controlled trial with 60 stressed adults. KSM-66 at 240mg/day was observed to support reductions in cortisol, improvements in sleep quality, and reductions in stress markers compared to placebo after 60 days. Demonstrated dose-dependent observations.
2012
Journal of Research in Medical Sciences
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
Double-blind RCT with 46 elderly subjects. Magnesium supplementation (500mg/day for 8 weeks) significantly improved subjective sleep quality, sleep time, sleep efficiency, and melatonin concentration while reducing cortisol levels compared to placebo.
2017
Nutrients
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress — A Systematic Review
Systematic review of 18 studies suggests magnesium supplementation may support stress markers and subjective well-being in stress-sensitive populations. Evidence suggests magnesium plays a role in modulating the HPA axis and supporting the body's stress response.
2021
Science
Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women
25 postmenopausal women with elevated glucose received 250mg/day NMN for 10 weeks. NMN improved muscle insulin sensitivity, insulin signaling, and muscle remodeling. The first randomized clinical trial to demonstrate metabolic benefits of NMN in humans.
2017
Journal of the International Society of Sports Nutrition
International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine
Comprehensive position stand reviewing 500+ published studies. Creatine monohydrate is the most effective ergogenic nutritional supplement for increasing high-intensity exercise capacity and lean body mass. Safe for long-term use at 3–5g/day with no adverse renal effects in healthy individuals.
2016
Andrologia
Clinical Evaluation of Purified Shilajit on Testosterone Levels in Healthy Volunteers
Randomized, double-blind, placebo-controlled trial with 96 healthy men (ages 45–55). 250mg purified shilajit twice daily for 90 days was observed to support healthy testosterone levels already within the normal range compared to placebo, along with supportive observations on DHEA.
Important Disclaimer
The studies listed are provided for educational purposes only. YourHealthier products are dietary supplements, not drugs. These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease. Results may vary.
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