NMN and Resveratrol: Sinclair's Stack, Honestly Reviewed

Quick Answer: The NMN + resveratrol stack is David Sinclair’s famous protocol: roughly 1 gram of NMN + 1 gram of trans-resveratrol every morning, with a fat source like yogurt or olive oil. The mouse evidence is real — Jiang et al. (2022) found the combo raised NAD+ by 1.6× in heart and 1.7× in muscle compared to NMN alone. But resveratrol has less than 1% oral bioavailability in humans, no head-to-head human trial has compared the stack to NMN-only, and the same mouse study found brain NAD+ dropped at six hours post-dose. For most people, 500 mg NMN delivers the bulk of the measurable benefit; adding resveratrol is a low-risk, modest-upside bet.

If you have spent more than ten minutes reading about longevity supplements, you have seen the NMN and resveratrol pairing. It has its own podcast appearances, a small army of brands selling pre-mixed powders, and a Harvard scientist who has been taking it daily for years. The case for the stack is built on a clean theoretical story: NMN supplies the NAD+ that sirtuin enzymes need as fuel, and resveratrol activates those sirtuins. Fuel plus pedal. But the human data is thinner than the marketing suggests, and the strongest mouse study on the combination also contains a finding everyone glosses over. This guide walks through what holds up, what does not, and how to make a sensible call.

Last reviewed: June 1, 2026 · Written by Tao Wu, Founder · Editorial Policy

Why NMN And Resveratrol Bundle People Stack NMN and Resveratrol

The pairing exists because the two molecules sit on opposite ends of the same pathway. NMN is a direct precursor to NAD+, the coenzyme that sirtuin enzymes need to do their job. Resveratrol is a sirtuin activator — it changes the shape of the SIRT1 enzyme to make it bind NAD+ more readily. In theory, more fuel plus a more efficient engine should produce more output than either alone.

That theory drove the original mouse work that launched the resveratrol field. The 2006 Baur et al. Nature paper showed resveratrol-fed obese mice on a high-fat diet had healthier organs and longer lifespans than controls. That, combined with Sinclair’s later NMN work showing NAD+ replenishment, set up the natural question: what happens if you give both? The 2022 Jiang study (which we walk through below) provided the first direct combination data — in mice.

The retail version of the stack arrived around 2018–2020 when brands like ProHealth, Renue by Science, and Wonderfeel started bundling NMN with resveratrol. Sinclair’s public protocol disclosure on the Joe Rogan and Lex Fridman podcasts in 2019–2021 sealed it. For more on NMN dosing alone (which underpins everything below), see our NMN dosage guide.

The Science: NAD+ Is the Fuel, Sirtuins Are the Engine, Resveratrol Is the Pedal

NAD+ (nicotinamide adenine dinucleotide) is one of the most-used coenzymes in the human body. It drives energy metabolism in mitochondria, donates electrons in the electron transport chain, and acts as a substrate for the sirtuin family of NAD+-dependent deacetylase enzymes. NAD+ levels decline with age — by some estimates, roughly 50% between the third and seventh decades of life.

NMN is the direct biochemical precursor to NAD+. Cells convert NMN to NAD+ via the NAMPT-NMNAT pathway in roughly one to two steps. The 2026 Christen et al. study in Nature Metabolism (PMID 41540253) confirmed that 1,000 mg of NMN per day roughly doubles circulating NAD+ levels in healthy humans within 14 days. That is the "fuel" half of the story.

Sirtuins (SIRT1 through SIRT7) are the "engine." They use NAD+ as a co-substrate to remove acetyl groups from histones and other proteins, regulating DNA repair, metabolic flexibility, inflammation, and cellular stress responses. SIRT1 specifically is the headline target for longevity research because it is the most extensively characterized in metabolic disease and aging models.

Resveratrol is the proposed "pedal." It binds to SIRT1 allosterically, changing the enzyme’s conformation so it has roughly 35-fold higher affinity for its substrate and 5-fold higher affinity for NAD+ (data from the original Sinclair-lab biochemistry work). In a cell-free assay this looks decisive. In a living human, as we will see in the counter-arguments section, it is more complicated.

Sinclair’s Protocol: What He Actually Takes

David Sinclair, PhD, professor of genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging, has publicly disclosed his personal supplement protocol multiple times. On the Lex Fridman Podcast (Episode 189, 2021), Found My Fitness with Rhonda Patrick, and in his book Lifespan (2019), Sinclair has stated: 1 gram of NMN in the morning with yogurt, 1 gram of trans-resveratrol mixed into the yogurt, 500–1000 mg of TMG (trimethylglycine) for methylation support.

The yogurt is not garnish. Resveratrol is fat-soluble, and Sinclair has explained the yogurt provides the fat needed to dissolve it for better intestinal absorption. The morning timing aligns with the body’s natural NAD+ circadian rhythm — levels are highest in the early hours and decline through the day.

It is worth being explicit about what Sinclair’s protocol is and is not. It is the personal practice of one prominent scientist who studies the field. It is not the result of a randomized controlled trial in humans. It is not an Anthropic-style recommendation. Sinclair himself has been careful to frame it as his own choice, not a prescription. Marketing copy that turns "Sinclair takes 1 gram" into "you should take 1 gram" is making a leap the evidence does not support.

Four Common Dose Ratios for the Stack

There is no consensus optimal ratio of NMN to resveratrol. Four main approaches dominate the market, each with a different reasoning. Match your goal and budget to the one that fits.

Approach	NMN	Resveratrol	Reasoning
Sinclair 1:1 (high)	1,000 mg	1,000 mg	Matches Sinclair’s personal protocol; ProHealth NMN Pro Complete uses this
Mid 1:1	500 mg	500 mg	Half the dose, half the cost; still inside the "active" range for both
Mid 2:1	500 mg	250 mg	Lean toward the better-evidenced ingredient (NMN) and treat resveratrol as a supporting role
Low-dose resveratrol	900 mg	50 mg	Wonderfeel’s approach; argues low-dose resveratrol is anti-apoptotic, high-dose is pro-apoptotic

Notice what the table is not showing: a clear winner from controlled human trials. None exists. The mouse combined effect data from Jiang et al. used a 10:1 NMN-to-resveratrol ratio (500 mg/kg NMN, 50 mg/kg resveratrol), which translates roughly to the Wonderfeel approach more than the Sinclair one. That is not proof Wonderfeel is right, but it is one of the few data points that exists.

Why Fat Matters: The Bioavailability Problem

Resveratrol’s biggest practical problem is not getting it into the body — that part works fine. The Walle et al. 2011 review (Ann NY Acad Sci, PMID 21261636) found oral absorption of resveratrol in humans is about 75%. The problem is keeping it intact. Aggressive first-pass metabolism in the intestine and liver converts it to glucuronide and sulfate metabolites almost immediately, leaving oral bioavailability of unmodified resveratrol below 1%.

That number is the reason resveratrol is contested. Most of what you swallow gets metabolized before it can reach a cell and bind SIRT1. Whether the conjugated metabolites retain meaningful biological activity is an active research question with mixed answers.

Sinclair’s yogurt strategy is one workaround. Resveratrol is fat-soluble, and consuming it with a fat source theoretically improves dissolution and absorption. The clinical data here is mixed — and actually unfavorable in at least one well-designed trial. The la Porte et al. 2010 study (Clin Pharmacokinet) directly compared 2 g of trans-resveratrol twice daily with a standard breakfast versus a high-fat breakfast in eight healthy adults; the high-fat meal decreased the area-under-the-curve by 45% and Cmax by 46%. The Linus Pauling Institute notes that bioavailability from red wine with a meal was similar to fasted, but supplemental resveratrol may behave differently depending on the formulation. The honest read: "take it with yogurt" is plausible mechanistically but not consistently supported. A modest amount of fat (not a high-fat meal) is the defensible middle path.

Other workarounds the industry has tried: micronized formulations (smaller particle size for faster dissolution), nano-formulations (lipid nanoparticles), liposomal delivery, and adding piperine (a CYP3A4 inhibitor that can slow first-pass metabolism). Each can improve plasma levels modestly. None has produced a definitive clinical breakthrough.

When to Take the Stack: Morning, With Food

Take both together in the morning, ideally with a fat-containing food. NAD+ peaks in the early hours through the SIRT1-CLOCK/BMAL1 circadian pathway, so morning NMN aligns with the body’s natural rhythm. Resveratrol needs the fat for absorption. Same window, same meal.

For deeper coverage of NMN timing alone, see Best Time to Take NMN. For the stack specifically, the consensus among prominent practitioners (Sinclair, Wonderfeel’s medical team) is morning + yogurt or olive oil. Avoid evening dosing unless you have a specific reason — both ingredients can be mildly stimulating for some people.

One practical note: capsules versus powder. Resveratrol degrades slightly in light and humidity, which is why bottles are usually dark glass. If you buy powder, store it sealed in a cool place and consume it within a few weeks of opening. Capsules are more stable.

What About TMG? The Methylation Question

TMG (trimethylglycine, also called betaine) is the third ingredient in Sinclair’s daily routine. The theory: NMN metabolism produces nicotinamide, which the body methylates to N-methylnicotinamide before excreting it. Heavy NMN dosing could in principle deplete the body’s methyl pool. TMG donates methyl groups and replenishes that pool.

The honest version: this concern is theoretical. No clinical trial has shown that NMN supplementation depletes methyl groups to a degree that causes problems in healthy adults. The methylation-depletion argument is plausible biochemistry, but it has not been demonstrated as a real issue in humans. Sinclair adds TMG as insurance, not as a documented requirement.

If you do add TMG, the standard recommendation is 500–1,000 mg per day, taken with NMN. The 1:1 ratio (500 mg NMN + 500 mg TMG, or 1 g + 1 g) is the most common formulation. The McRae 2013 work showed TMG can also lower plasma homocysteine, which is a separate cardiovascular benefit unrelated to NMN.

What the Critics Say

The NMN + resveratrol stack has more critics than its marketing acknowledges. Four objections are worth taking seriously.

1. Resveratrol’s bioavailability problem is unresolved

Charles Brenner, PhD, and other NAD+ researchers have argued that resveratrol’s poor oral bioavailability means most of the dose never reaches the cells where SIRT1 lives. Walle 2011 documented this directly: less than 1% of an oral dose reaches systemic circulation as unmodified resveratrol. The hopeful counter-argument is that conjugated metabolites may retain some activity. The honest version is that the question is not settled. Sinclair himself, on the Found My Fitness podcast, has called resveratrol a "dirty molecule" and acknowledged the bioavailability problem.

2. The pharmaceutical industry tried and gave up

GlaxoSmithKline acquired Sirtris Pharmaceuticals (the company Sinclair co-founded around resveratrol-like sirtuin activators) in 2008 for $720 million. The lead compound, SRT501, was a micronized formulation of resveratrol designed to improve bioavailability. Phase II trials for multiple myeloma were halted in 2010 due to renal toxicity in some participants. GSK eventually shuttered the Sirtris program. That history is not a death sentence for resveratrol — it tested a specific drug-like dose, not a supplement dose — but it should temper enthusiasm.

3. The combined effect data is from mice, and the brain finding gets buried

Jiang et al. (2022, PMID 35844164) is the most-cited combined effect study. The headline is real: NMN + resveratrol raised NAD+ by 1.6× in heart and 1.7× in skeletal muscle versus NMN alone. But the same paper found that the combination reduced brain NAD+ at six hours post-dose compared to NMN alone. That finding is rarely quoted in marketing copy. It does not mean the combo is harmful — but it does mean the combined effect is tissue-specific, not universal, and the long-term consequences of altered brain NAD+ are unknown. Also: this was a mouse study with n=3 per time point. It is suggestive, not confirmatory.

4. NOVOS Labs skips resveratrol entirely

NOVOS Core, one of the more research-driven longevity formulas on the market, uses pterostilbene instead of resveratrol. Their reasoning, published openly: pterostilbene has substantially higher oral bioavailability than resveratrol (some preclinical work suggests 4–5×), circulates longer in the body (~105 minutes vs ~14 minutes for resveratrol), and activates similar SIRT1 pathways. NOVOS argues, plausibly, that pterostilbene is the better practical choice for the same biological target. Whether they are right depends on more human data than currently exists, but the position is defensible.

None of these objections kills the stack. They do mean honest discussion of the NMN + resveratrol combination should not pretend it is a settled science.

How the Pathway Works (Visual)

The dashed line on resveratrol is intentional. Whether the molecule reaches the SIRT1 protein in meaningful concentrations after oral dosing is the open question the entire field rests on.

Top NMN + Resveratrol Combo Products

If you decide to run the stack, you have two paths: buy a pre-mixed combo product, or buy NMN and trans-resveratrol separately. The combo products simplify dosing but lock you into one brand’s ratio. Separate products give you control. Here is what the major combo offerings look like as of May 2026.

Product	NMN	Resveratrol	Other	Approx Price
ProHealth Longevity NMN Pro Complete	1,000 mg	1,000 mg (trans)	500 mg TMG; Uthever® NMN	~$120 / 30 servings
Wonderfeel Youngr	900 mg	50 mg	Hydroxytyrosol, ergothioneine, vit D3	~$88 / 30 servings
NOVOS Core	none	none (pterostilbene 50 mg)	Fisetin, Ca-AKG, glycine, glucosamine, etc	~$95 / 30 sachets
Thorne ResveraCel	none (NR 300 mg)	150 mg	Quercetin, betaine; Niagen® NR	~$60 / 30 servings
DIY stack: YourHealthier NMN + 3rd-party trans-resveratrol	500 mg	your choice	Full ratio control	Variable

Two observations. First, only ProHealth attempts the Sinclair 1g+1g protocol; you pay for it. Second, NOVOS and Thorne actually opt out of the canonical NMN + resveratrol formula — NOVOS replaces resveratrol with pterostilbene, Thorne replaces NMN with NR. Both choices reflect real research debates, not laziness. Choosing among these is choosing which scientific bet you find more persuasive.

Why We Don’t Sell a Combo Product

We sell a 500 mg NMN capsule. We do not sell resveratrol, and we do not currently bundle the two. That is a deliberate choice, and being honest about why is more useful than pretending we have a combo product to push.

The reasoning: the NMN evidence is meaningfully stronger than the resveratrol evidence. NMN has at least a dozen peer-reviewed human RCTs documenting NAD+ elevation and functional benefits (we walk through them in the NMN dosage guide). Resveratrol has decades of mechanistic and mouse work, but the human bioavailability problem and the failure of the SRT501 drug-development effort suggest the case in humans is weaker. We would rather sell one product with confident dosing than two products where we have to caveat the second.

If you want to run the stack, here is the honest recommendation: take our 500 mg NMN capsule in the morning, and pair it with a third-party trans-resveratrol product (50 mg if you trust the low-dose research, 500–1,000 mg if you want to mirror Sinclair). Take both with a yogurt or olive oil. We are not going to make money on the resveratrol half, but you will end up with a defensible stack at a meaningfully lower cost than the combo products above.

If a combo product genuinely appeals to you, ProHealth’s NMN Pro Complete is the closest match to Sinclair’s exact ratios, and Wonderfeel’s Youngr is the best low-resveratrol option. Both are reputable. Neither is cheap.

NMN, Resveratrol, and the Sinclair Conversation, on Video

David Sinclair walks through his personal NMN + resveratrol + yogurt protocol on the Lex Fridman Podcast (Episode 189). The full conversation also covers his views on metformin, the sirtuin hypothesis, and why he believes the supplement field is moving toward NAD+ precursors.

Related Research

• PubMed: 27721479
• PubMed: 36476934
• PubMed: 27304511
• PubMed: 35821806
• DOI: 10.1002/fft2.511
• PubMed: 37619764
• PubMed: 35927255

Related Reading

• NMN Before and After: Real Results from 8-Week Use (2026)
• NMN vs NAD: What's the Difference? (2026 Science Guide)
• Best Time to Take NMN: Morning or Night? (2026 Guide)
• NMN Side Effects: What the Clinical Trials Report (2026)
• NMN vs NR: Which NAD+ Precursor Is Better? (2026 Data)
• NMN Dosage: How Much Per Day? 250mg vs 600mg vs 1000mg
• NMN Benefits: NAD+ for Aging & Energy (2026)

What's new in NMN research: 2025–2026

More than 12 controlled human studies now cover NMN, testing doses up to 1,250 mg/day for periods of 4–12 weeks. NAD+ elevation is reproducible across protocols, and the adverse-event profile has remained clean so far.

What resveratrol adds to NMN: the sirtuin activation hypothesis

The rationale for combining NMN with resveratrol originates from David Sinclair's sirtuin-centric aging model. The theory: NAD+ (produced from NMN) is the cosubstrate that sirtuins need to function, while resveratrol may activate SIRT1 directly. NMN provides the fuel; resveratrol turns on the engine. In this framework, taking both simultaneously produces greater sirtuin activation than either alone.

The evidence for this framework is stronger in preclinical models than in humans. The Baur 2006 mouse study found that resveratrol improved healthspan in obese mice on a high-fat diet. Subsequent mouse studies combining NR (a related NAD+ precursor) with resveratrol showed additive effects on mitochondrial biogenesis. However, human trials of resveratrol alone have produced mixed and often disappointing results. The Timmers 2011 study found metabolic improvements at 150 mg/day in obese men, but several subsequent trials failed to replicate these findings in different populations.

The practical question: does adding resveratrol to NMN produce better outcomes than NMN alone? No human trial has tested this specific combination. The rationale is mechanistically sound but empirically untested. If you are already taking NMN and considering adding resveratrol, the potential upside is enhanced sirtuin activation, the potential downside is additional cost ($30 to $60/month for quality resveratrol) with uncertain incremental benefit. Resveratrol at 150 to 500 mg/day with a fat-containing meal (resveratrol is fat-soluble) is the protocol most consistent with the positive studies. For NMN dosing protocols, see NMN dosage.

Practical protocol for the NMN-resveratrol combination

If you decide to try both compounds together, here is a protocol consistent with the available pharmacological data. Morning dosing for both, with a meal containing fat (eggs, avocado, olive oil): NMN 250 to 500 mg (sublingual or capsule, taken first) followed by resveratrol 150 to 500 mg (trans-resveratrol specifically, as it is the bioactive isomer). The fat-containing meal is critical for resveratrol because it is highly lipophilic and its oral bioavailability increases 3 to 5 fold when consumed with dietary fat.

Start with the lower end of both doses for the first 2 weeks, then escalate if tolerated. NMN at 250 mg and resveratrol at 150 mg is the conservative starting point. The most commonly cited protocol among longevity researchers who publicly disclose their stacks (Sinclair, Attia) uses NMN 500 to 1,000 mg plus resveratrol 500 mg to 1 g, though these are personal protocols rather than clinically validated doses.

What to monitor: the same markers recommended for NMN alone (NAD+ levels via specialty lab, fasting glucose, inflammatory markers) plus liver enzymes (AST, ALT) at 8 weeks, because resveratrol at high doses has occasionally been associated with transient liver enzyme elevation in clinical trials. If AST or ALT increase beyond 2x the upper limit of normal, discontinue resveratrol and retest in 4 weeks. For the NMN-specific evidence, see NMN benefits. For dosing details, see NMN dosage.

The Sinclair protocol context: where this combination originated

The NMN plus resveratrol combination gained public visibility primarily through David Sinclair, PhD, Professor of Genetics at Harvard Medical School, who has publicly discussed his personal supplementation regimen in interviews and his book Lifespan. Sinclair's stated rationale: NMN raises NAD+ levels (providing the substrate), while resveratrol activates SIRT1 (providing the enzyme demand). Together, they theoretically create a "supply meets demand" scenario for sirtuin-mediated cellular maintenance.

Important caveats: Sinclair's personal regimen is not a clinical recommendation. It is an individual researcher's interpretation of preclinical data applied to himself. No published RCT has tested the NMN + resveratrol combination in humans for any endpoint. The sirtuin activation claim for resveratrol itself is contested — the Pacholec 2010 study questioned whether resveratrol directly activates SIRT1 or works through an indirect mechanism. Sinclair's lab has published rebuttals, but the scientific community has not reached consensus.

What the individual compound data shows: NMN raises blood NAD+ in humans (12+ RCTs). Resveratrol at 150 to 500 mg/day has shown modest improvements in some metabolic markers in human trials, but results are inconsistent — the Timmers 2011 study found positive metabolic effects, while the Poulsen 2013 study found none. The combination may work through complementary mechanisms, but "may" is doing heavy lifting in that sentence. For the NMN evidence alone, see NMN benefits.

NMN and resveratrol dosage: what the research suggests

No trial has tested the NMN + resveratrol combination, so dosing recommendations are extrapolated from individual compound trials. NMN: 250 to 500 mg/day in the morning (based on the Igarashi 2022 and Yi 2023 protocols). Resveratrol: 150 to 500 mg/day with a fat-containing meal (resveratrol is fat-soluble, and the Timmers 2011 study used 150 mg/day with meals). Some longevity researchers take higher resveratrol doses (1,000 mg/day), but the dose-response curve in humans is not established and GI discomfort increases above 500 mg/day in some individuals. See NMN dosage.

Who should be cautious with NMN

People with active or prior cancer. NMN raises NAD+ levels, which fuel cellular metabolism. Because cancer cells also rely on NAD+ for rapid growth, there is theoretical concern that boosting NAD+ could support tumor metabolism. The human evidence is unsettled, but anyone with a current or past cancer diagnosis should discuss NMN with their oncologist before using it.

Pregnant or breastfeeding women. There is no safety data for NMN during pregnancy or lactation. Avoid use during these periods.

People taking medications. NMN's interactions are not well characterized because it is a relatively new supplement. If you take any prescription medication, particularly for metabolic or cardiovascular conditions, consult your doctor first.

People expecting dramatic anti-aging effects. While NMN reliably raises NAD+ levels in humans, the longevity and anti-aging benefits demonstrated in mice have not yet been confirmed in large human trials. Set expectations accordingly and treat marketing claims with skepticism.

NMN appears well tolerated in short-term human studies, but its regulatory status has shifted in the United States, and long-term safety data is still developing. More detail: NMN benefits and the current evidence.

Frequently Asked Questions

Related Reading:

• NMN Dosage: How Much Per Day? 250mg vs 600mg vs 1000mg
• NMN Benefits: What NAD+ Actually Does for Aging and Energy (2026)
• NMN vs NR: Which NAD+ Precursor Is Better? (2026 Data)
• NMN Side Effects: What the Clinical Trials Report (2026)
• Best Time to Take NMN: Morning or Night? (2026 Guide)
• NMN Before and After: Real Results from 8-Week Use (2026)
• Best Supplements for Sleep: A Science-Based Ranking (2026)
• Creatine for Brain Health: Not Just for Athletes (2026)
• Ashwagandha Benefits: 7 Reasons It’s the Most Popular Adaptogen
• Magnesium Glycinate Benefits: 7 Reasons It Beats Other Forms (2026)
• Berberine Benefits: What It Does for Blood Sugar, Metabolism, and More
• Shilajit Benefits: 8 Effects Ranked by Evidence (2026)

What is NMN and what is an NMN supplement?

NMN is the NAD+ precursor; resveratrol is the sirtuin activator often stacked with it. NMN (nicotinamide mononucleotide) raises NAD+, the energy coenzyme that falls with age, while resveratrol is theorized to help the enzymes that use it, which is the logic behind taking them together. It is sold as a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.

References

1. Christen S, Redeuil K, Goulet L, et al. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans. Nature Metabolism. 2026;8(1):62–73. PubMed
2. Jiang Y, Liu S, Wu Z, et al. Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacol Res Perspect. 2022;10(4):e00986. PubMed
3. Walle T. Bioavailability of resveratrol. Ann N Y Acad Sci. 2011;1215:9–15. PubMed
4. Brenner C. Comment on "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science. 2021;373(6554):eabj1696. PubMed
5. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229. PubMed
6. Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults. GeroScience. 2023;45(1):29–43. PubMed
7. Howells LM, Berry DP, Elliott PJ, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases. Cancer Prev Res. 2011;4(9):1419–1425. PubMed
8. la Porte C, Voduc N, Zhang G, et al. Steady-state pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol in healthy human subjects. Clin Pharmacokinet. 2010;49(7):449–454. PubMed
9. Smoliga JM, Blanchard O. Enhancing the delivery of resveratrol in humans. Molecules. 2014;19(11):17154–17172. PubMed
10. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337–342. PubMed
11. Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood NAD levels and alters muscle function in healthy older men. NPJ Aging. 2022;8:5. PubMed

Disclosure: YourHealthier sells NMN. We do not sell resveratrol or NMN+resveratrol combos. This article is written by our editorial team based on peer-reviewed research. We cite only published clinical trials and disclose where the evidence is limited or contested. See our Editorial Policy for how we research and write.

⚠️ These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, under 18, or taking medication.

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