Codeage GLP-Harmony Companion+ Review 2026: A Gut-and-Brain Formula With No Vitamins

What Codeage GLP-Harmony Companion+ Is

GLP-Harmony Companion+ is a 60-capsule supplement from Codeage, a US brand known for multi-ingredient and liposomal formulas. The label calls for two capsules daily with water, ideally 30 minutes before the largest meal. It sold for $39.99 at Vitacost, GNC and Grove and $41.99 at Walmart when we checked on October 17, 2026. Retail listings for it date back to 2024, before most GLP-1 companion products launched.

We found Codeage products at GNC, Vitacost, Walmart and Grove. The brand sells a wide range, from fermented multivitamins to collagen and nootropic blends, often with a liposomal or time-release delivery system. GLP-Harmony Companion+ is one of its GLP-1 products; the brand also sells a GLP-1 probiotic and a GLP-Advantage formula, which this review does not cover.

Marketing for this product is careful. When we read the retail copy on October 17, 2026, it described the formula as a blend that may "potentially complement the wellness regimen of GLP-1 receptor agonist users." Grove's listing adds that it is meant to help people "experiencing gastrointestinal discomfort." It does not claim to replace medication, boost GLP-1 levels or cause weight loss.

From the listings we reviewed: made in the USA in a cGMP-certified facility with globally sourced ingredients; non-GMO, gluten free, soy free and corn free; contains milk, from the bovine colostrum. The capsule is hypromellose. The other ingredients include vegetable fiber or microcrystalline cellulose and a phospholipid complex from sunflower oil and lecithin, which Codeage calls its "liposomal time-release matrix."

The Ten Ingredients Against the Doses That Were Studied

Three ingredients have human trials we could check: Lion's Mane (a 16-week trial used about 3 g a day of dried powder), PEA (a meta-analysis of 11 chronic pain trials) and Akkermansia (a pilot trial used 10 billion bacteria a day). Codeage's amounts are lower or not directly comparable. The other seven ingredients appear in smaller amounts without a GLP-1-specific rationale we could trace.

Ingredient (per 2 capsules)	Amount	Human research we checked	How the amount compares
Lion's Mane fruiting body extract	500 mg	Mild cognitive impairment trial, about 3 g a day of dried powder for 16 weeks	Different form; extract strength not stated
Palmitoylethanolamide (PEA)	300 mg	Meta-analysis of 11 chronic pain trials, 774 patients	Trial doses not listed in the abstract
Bovine colostrum	200 mg	Not reviewed here	Small amount
Shilajit resin extract	100 mg	Not reviewed here	Small amount
Elder fruit extract	100 mg	Not reviewed here	Antioxidant group
Blueberry fruit powder	50 mg	Not reviewed here	Antioxidant group
Citrus bioflavonoids complex	50 mg	Not reviewed here	Antioxidant group
Broccoli seed extract	25 mg	Not reviewed here	Antioxidant group
Akkermansia muciniphila	20 mg (1 billion CFU at manufacture)	Pilot trial, 10 billion bacteria a day for 3 months	One-tenth of the trial amount, counted at manufacture
Trans-resveratrol	10 mg	Not reviewed here	Small amount

"Not reviewed here" means we did not evaluate that ingredient's research for this article, not that none exists. The point of the table is narrower. For the three ingredients most central to the formula, we compared the amounts with the trials that tested them.

What the Formula Leaves Out

GLP-Harmony Companion+ contains no vitamins, no minerals and no protein. Published GLP-1 nutrition research most often flags protein, vitamin D, iron, vitamin B12, folate and zinc as shortfalls, and case reports single out thiamine in people with prolonged vomiting. None of these are in the product, so anyone taking it for nutritional support during GLP-1 therapy needs those covered elsewhere.

This is the single most important fact for a shopper to know, and we nearly missed it ourselves. Most products sold under a GLP-1 companion label are built around micronutrient replacement. This one is not. The label is accurate; it simply lists a different kind of formula.

What GLP-1 users tend to lack is consistent across studies. When 387 adults on once-weekly GLP-1 or GIP/GLP-1 drugs logged two days of meals, they averaged 753 kcal and 33.4 g of protein a day, and fewer than one in ten reached recommended protein. The authors described the group as short on protein and critical micronutrients (Korus et al., 2026). Among 2,031 adolescents in claims data who began a GLP-1 drug, roughly one in six received a deficiency-related diagnosis within a year, with vitamin D the most common (Kerr et al., 2026). Those patients were 10 to 17, and the analysis came from Abbott Nutrition staff, so it points to a pattern rather than an adult rate.

A 2026 review written for aesthetic practitioners, looking at skin and hair changes during treatment, kept returning to protein, vitamin D, iron, B12, folate, zinc and copper (Karlin et al., 2026). Thiamine is on the radar for a different reason. Reports of Wernicke encephalopathy, the brain injury caused by severe thiamine deficiency, are rare among GLP-1 users, 15 in one 2026 review of FDA data and published cases, but nearly all followed vomiting, poor appetite or malnutrition (Lev et al., 2026).

Two broad reviews from 2026 frame the same priorities: protein adequacy, lean mass and micronutrient status (Sorić et al., 2026), alongside gastrointestinal side effects and reduced energy intake (Kwaśny et al., 2026). Codeage's formula touches the gastrointestinal theme through Akkermansia and colostrum. It does not address the others.

Akkermansia: The Ingredient With the Most GLP-1 Interest

Akkermansia muciniphila is a gut bacterium linked to metabolic health in observational studies. In a 2019 pilot trial, 10 billion bacteria a day for three months was safe, and the pasteurized form improved insulin sensitivity by about 29% compared with placebo. Codeage provides 1 billion CFU, counted at manufacture, and does not state on the listings whether the bacteria are live or pasteurized.

Akkermansia lives in the mucus layer that lines the gut. People with obesity and type 2 diabetes tend to have less of it, which made it a candidate for supplementation. The first human trial, by Depommier and colleagues, enrolled 40 overweight or obese adults with insulin resistance, and 32 completed it. Participants took 10 billion live or pasteurized bacteria a day, or placebo, for three months. Both forms were safe and well tolerated. Compared with placebo, the pasteurized form improved insulin sensitivity by about 29% (Depommier et al., 2019). It was a small pilot study, and its authors described it as exploratory.

Any connection to GLP-1 specifically is still mostly laboratory work. A 2025 study found that extracts of one Akkermansia strain raised GLP-1 secretion in a human intestinal cell line (Arukha et al., 2025). Cell-culture results like this are a starting point, and the study was run by a company that supplies the strain. It does not tell us what a capsule does in a person already taking semaglutide or tirzepatide, whose GLP-1 receptor is being stimulated by the drug at levels far above anything gut bacteria could produce.

For anyone buying mainly for the Akkermansia, three details matter. The amount, 1 billion CFU, is one-tenth of the 10 billion used in the Depommier trial. The count is stated "at time of manufacture," and live bacteria decline in storage, so the number reaching you can be lower; products that give a count at expiration offer the more conservative figure.

A third detail is the form. The listings we checked did not say whether the bacteria are live or pasteurized, and in the pilot trial it was the pasteurized form that showed the clearer metabolic effects. Akkermansia is also very sensitive to oxygen, which makes keeping live cells viable in a standard bottle hard. If this ingredient is your reason for buying, ask Codeage which form it uses and how viability is maintained.

Lion's Mane and PEA: Real Evidence, Different Questions

Lion's Mane improved cognitive scores in older adults with mild cognitive impairment in a 16-week trial, and the benefit faded after people stopped. PEA reduced pain scores in a meta-analysis of chronic pain trials. Neither ingredient has been studied in people taking GLP-1 drugs, and neither addresses the nutritional gaps those drugs can create.

Lion's Mane

In the best-known human trial, 30 Japanese adults aged 50 to 80 with mild cognitive impairment either Lion's Mane or placebo. The treatment group took four 250 mg tablets of 96% dried mushroom powder three times a day for 16 weeks, about 3 g a day. Cognitive scores rose significantly at weeks 8, 12 and 16 compared with placebo, then fell four weeks after people stopped (Mori et al., 2009).

Codeage uses 500 mg of a fruiting-body extract. Extracts concentrate some compounds, so 500 mg of extract is not simply one-sixth of 3 g of powder; it could be more or less potent depending on the extraction ratio, which the listings do not state. The fair summary is that the dose cannot be compared directly with the trial.

Some GLP-1 users describe mental fog, especially early in treatment or when eating very little. Low intake, poor sleep, dehydration and low B12 or iron are the more common explanations, and a blood test can rule the nutritional ones in or out. Lion's Mane is a reasonable thing to be curious about. That check still comes first. For more on the mushroom itself, see our guide to the best Lion's Mane supplements.

Palmitoylethanolamide (PEA)

PEA is a fatty acid amide the body makes on its own. A 2023 meta-analysis pooled 11 double-blind randomized trials with 774 patients with chronic pain and found that PEA reduced pain scores compared with placebo or active comparators (Lang-Illievich et al., 2023). The abstract does not list the doses used, so we cannot say whether 300 mg matches them.

Chronic pain and inflammation are not typical side effects of GLP-1 drugs. PEA could still suit a GLP-1 user who also lives with chronic pain, but that is a separate reason for taking it, unrelated to the medication.

Colostrum, Shilajit and the Antioxidant Group

Seven remaining ingredients total about 535 mg and include bovine colostrum (200 mg), shilajit (100 mg), elder fruit (100 mg), blueberry powder (50 mg), citrus bioflavonoids (50 mg), broccoli seed extract (25 mg) and trans-resveratrol (10 mg). Codeage does not tie any of them to a specific GLP-1 side effect, and we did not evaluate their research for this review.

Colostrum is the first milk produced after a cow gives birth. It contains antibodies and growth factors and has been studied for gut barrier function and athletic recovery. It is also the reason the label says "contains milk," which matters for anyone with a dairy allergy.

Shilajit is a mineral-rich resin from mountain rock used in Ayurvedic practice. Despite its mineral content, it does not supply a measured amount of any specific mineral the way a supplement that lists "magnesium 200 mg" would be. We cover it in more depth in our article Does Shilajit Work?

Five plant ingredients form an antioxidant group. At 10 to 100 mg each, they add variety to the label. Whether they add a measurable effect at these amounts is not something the listings attempt to show.

The "Liposomal Time-Release Matrix"

Codeage describes a phospholipid complex from sunflower oil and lecithin as a liposomal time-release delivery system. Liposomal delivery can improve absorption for some compounds, but we found no published data on how it changes absorption for this particular combination of ingredients.

Liposomes are tiny fat-based spheres that can carry compounds through the gut, and they have shown absorption benefits for some nutrients in research settings. Whether a phospholipid complex mixed into a capsule forms true liposomes, and whether it changes how much Lion's Mane, PEA or colostrum reaches the bloodstream, are separate questions. Codeage's listings describe the matrix without citing a study on this formula.

We found no absorption data for this particular combination, which is common across the supplement industry and not unique to Codeage. "Liposomal" and "time-release" describe how a product is made, not how well it works. A shopper should treat them as manufacturing details unless the brand shares absorption data for the specific product.

If You Already Take It: What to Add

If GLP-Harmony Companion+ is already part of your routine, keep it if you value its ingredients, and fill the gaps around it: a protein plan, a micronutrient source chosen with your labs, and a clear sense of which symptoms need a call to your prescriber rather than another supplement.

If you bought this product because of the "GLP-1" in its name and assumed it covered your nutritional bases, adjust your expectations rather than your bottle. If that describes you, nothing about the product is harmful to keep taking. What changes is the list of things to handle elsewhere.

Start with protein. Aim for it at every meal, and use a powder or ready-to-drink shake on days when appetite is very low. In the 2026 diet study described above, average protein intake was 33.4 g a day, far below what most guidance suggests during weight loss.

Vitamin D. Ask your prescriber whether your risk factors call for testing or a specific dose. Many GLP-1 users have obesity or diabetes, which puts them in higher-risk groups.

Test B12, folate and iron. These three are the usual suspects when energy drops. A blood count, ferritin and B12 level answer the question faster than any supplement trial and error.

Keep thiamine on your radar. You do not need to worry about it on ordinary days. You do need to call your prescriber if you have vomited for more than a day or two, or if you notice new numbness, unusual weakness, trouble swallowing or confusion. The authors of a 2026 semaglutide case report urged clinicians to suspect thiamine, folate and B12 deficiency in exactly those situations, because prompt replacement can limit nerve injury (Cohan et al., 2026).

Bring a photo of every supplement label to your next appointment. A one-minute review of the full list is often more useful than adding another bottle.

Five Questions Worth Asking Codeage

Several details remain open on the listings that would help a buyer judge this formula: whether the Akkermansia is live or pasteurized, its count at expiration, the Lion's Mane extract ratio, the PEA particle size and the availability of a batch certificate of analysis. Codeage's customer service is the place to ask.

None of these gaps are unusual in the supplement market. They matter here because the formula's case rests on specific ingredients rather than on broad nutrient coverage, so the details of those ingredients carry more weight.

1. Is the Akkermansia live or pasteurized, and how is it kept viable? The two forms behaved differently in the only human trial, and live Akkermansia is hard to keep alive outside an oxygen-free environment.

2. What is the Akkermansia count at expiration? The label gives the count at manufacture. The number on the day you swallow the capsule is the one that matters.

3. What is the Lion's Mane extract ratio, and is it standardized for any compounds? Without that, 500 mg of extract cannot be compared with the dried powder used in trials.

4. Is the PEA micronized? Some PEA products use reduced particle size to improve absorption. The listings do not say which kind is used here.

5. Can you share a certificate of analysis for my lot number? This is a reasonable request for any supplement, and the answer tells you a lot about a brand's testing practices.

Who Might Choose It

GLP-Harmony Companion+ fits a GLP-1 user who already covers protein and micronutrients through food, labs and other supplements, and who specifically wants Lion's Mane, PEA, colostrum and Akkermansia in one capsule. It does not fit someone looking for a single product to cover the nutritional side of GLP-1 therapy.

Consider it if your recent labs were normal, your clinician is not asking you to take any particular vitamin or mineral, you are eating enough protein, and you are interested in these specific ingredients for their own sake. Taking them together in two capsules is convenient, and at $1.33 a day the price is in line with other multi-ingredient formulas.

Look elsewhere if you want help with nutrient shortfalls during GLP-1 therapy. Vitamin D, B12, iron, folate, zinc and thiamine all need another source. Neither is it a solution for lean mass loss on Ozempic, which depends on protein and resistance training.

Talk to your prescriber first if you have a dairy allergy (colostrum), you are pregnant or breastfeeding, or you take medications that your pharmacist would want to review against any new supplement. The label also recommends taking the capsules 30 minutes before the largest meal; people with significant nausea may find that timing harder.

Building a GLP-1 Routine Around It

If you want Codeage's ingredients and also want nutritional coverage, the practical approach is to pair it with a micronutrient source and a protein plan, then let your labs guide doses. Treat the two products as separate layers rather than expecting one to do both jobs.

A layered approach might look like this. Protein comes first. Most guidance for people losing weight quickly emphasizes protein at each meal, and a powder can help on low-appetite days. Micronutrients come second, from either a broad multivitamin or a GLP-1-focused formula chosen with your lab results in mind. We make one, the YourHealthier GLP-1 Companion ($47.99 for 30 days on our site on October 17, 2026), so weigh that mention accordingly; lower-cost multivitamins also exist. Third, anything optional, which is where a product like GLP-Harmony Companion+ fits.

Keep a running list of every supplement and its main amounts. When products overlap, totals add up, and when they do not overlap, gaps stay open. Our GLP-1 nutrition checklist lists the nutrients most often discussed with prescribers, and our article on GLP-1 side effects explains which symptoms need prompt attention regardless of what supplements you take.

Dietitians who work with GLP-1 patients describe the job as structured care: assessment, a personalized eating plan, protein targets, help with digestive symptoms and follow-up (Balasubaramaniam et al., 2026). Supplements are one piece of that, and the most useful ones are chosen after the assessment rather than before.

Judging It on Its Own Terms

Codeage GLP-Harmony Companion+ is a multi-ingredient gut, brain and antioxidant formula, made by an established brand, with careful marketing. It has no vitamins, minerals or protein, and its three best-studied ingredients appear at amounts that are lower than, or not comparable to, the trials behind them. It can be an add-on for someone whose nutrition is already covered. As a nutritional companion in the sense most GLP-1 users need, it falls short.

Inevitably, the product's name invites comparison with GLP-1 multivitamins, and on that comparison it will look thin. Judged on its own terms, it is a reasonable combination of ingredients people are curious about, from a brand with a long retail track record. The mismatch is between the label category and the formula, and Codeage's own cautious wording does not overstate it.

What this formula leaves out on the vitamin and mineral side is covered in our GLP-1 supplement roundup and in our Mounjaro and Zepbound vitamin guide.

Frequently Asked Questions

Does Codeage GLP-Harmony Companion+ contain any vitamins or minerals?

No. Its ten ingredients are Lion's Mane extract, PEA, bovine colostrum, shilajit, elder fruit extract, blueberry powder, citrus bioflavonoids, broccoli seed extract, Akkermansia muciniphila and trans-resveratrol. If you need vitamin D, B12, iron, magnesium or other micronutrients, they must come from food or another supplement.

Is the Akkermansia in GLP-Harmony Companion+ live?

According to the listings we checked, the product provides 1 billion CFU "at time of manufacture" but do not say whether the bacteria are live or pasteurized. In the main human trial, the pasteurized form at 10 billion bacteria a day produced the clearer metabolic results (Depommier et al., 2019). Codeage's customer service can confirm the form.

Does GLP-Harmony Companion+ increase GLP-1 levels?

Codeage does not claim that it does. Lab studies have explored whether Akkermansia extracts affect GLP-1 secretion in cell cultures (Arukha et al., 2025), but there is no human evidence that this product changes GLP-1 levels, and people taking GLP-1 medications already receive far more receptor stimulation from the drug.

How should GLP-Harmony Companion+ be taken?

Take two capsules daily with 8 ounces of water, preferably 30 minutes before the largest meal. It contains milk from bovine colostrum. As with any supplement, review it with your prescriber or pharmacist if you take other medications.

Is Codeage a legitimate brand?

Yes. Codeage is a US supplement company whose products are sold through major retailers including GNC, Vitacost, Walmart and Grove, and it states that it manufactures in cGMP-certified facilities. The question for this product is fit rather than legitimacy. It is a gut, brain and antioxidant formula rather than a micronutrient supplement.

Other GLP-1 Companion Supplement Reviews

We reviewed six GLP-1-labeled supplements against the same evidence and the same October 17, 2026 pricing. Each takes a different approach, and no single product covers everything a GLP-1 user needs.

The rest of the series:

• Centrum Nutrient Replenish
• vitafusion GLP-1 Support gummies
• GLP-1 SOS Daily Gut Relief
• SoWell GLP-1 Support System
• Nature Made GLP-1 Companion (discontinued)

References

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